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Related Experiment Video

Updated: Jul 17, 2026

Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice
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Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice

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A 96-channel neural stimulation system for driving AIROF microelectrodes.

Z Hu1, P Troyk, S Cogan

  • 1Illinois Institute of Technology, Chicago, IL, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
Summary

This study introduces a 96-channel system for safe neural stimulation using activated iridium oxide (AIROF) microelectrodes. The novel design enhances charge injection capacity for visual prosthesis research.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Traditional neural stimulation systems face limitations in charge injection capacity and microelectrode safety.
  • Activated iridium oxide (AIROF) microelectrodes offer potential for high-performance neural interfaces but require careful drive circuitry.
  • Developing safe and efficient stimulation systems is crucial for advancing neural prosthetics.

Purpose of the Study:

  • To design and test a 96-channel stimulation system for AIROF microelectrodes.
  • To enhance charge-injection capacity while maintaining microelectrode safety.
  • To provide a computer-controlled platform for intracortical neural stimulation.

Main Methods:

  • Development of a 96-channel stimulation system using custom PCB boards, ASIC chips, and a motherboard.

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Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
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Last Updated: Jul 17, 2026

Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice
10:44

Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice

Published on: July 5, 2013

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
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Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

  • Implementation of a modified stimulation waveform to maximize charge injection.
  • Integration with a PC interface including a DIO card and custom software.
  • Testing of the system to ensure safe operation within charge-injection limits.

    • Main Results:

    • Successful design and testing of a 96-channel stimulation system for AIROF microelectrodes.
    • Demonstration of a system capable of delivering computer-controlled cathodic current pulses.
    • Validation of the system's ability to positively bias microelectrodes during inter-pulse intervals.
    • Confirmation that the system operates within safe charge-injection limits for AIROF microelectrodes.

    Conclusions:

    • The developed 96-channel stimulation system effectively drives AIROF microelectrodes safely and efficiently.
    • This system represents an improvement over traditional methods, maximizing charge-injection capacity.
    • The system is suitable for use in animal experiments for visual prosthesis research and intracortical neural stimulation.