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Updated: Jul 17, 2026

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
PAM: passive marker-based analyzer to test patients with neural diseases
1Department of Measurement & Information Systems, Budapest University of Technology & Economics, Hungary.
Summary
Early detection of neurological diseases is improved by analyzing patient movement coordination. A new, affordable motion analysis system quantifies movement speed and regularity for better disease staging.
Area of Science:
- Neurology
- Biomedical Engineering
- Movement Science
Background:
- Subtle changes in patient movement coordination in early neurological disease stages are often undetectable by visual inspection.
- Objective evaluation of movement patterns is crucial for early diagnosis and disease staging.
- Existing motion analysis systems are highly accurate but prohibitively expensive for routine clinical use.
Purpose of the Study:
- To develop an affordable motion analysis device for routine clinical use in diagnosing and staging neurological diseases.
- To identify key movement parameters relevant to neurologists for assessing disease progression.
Main Methods:
- Utilized passive marker-based motion analysis, known for its non-invasiveness and accuracy.
- Developed a cost-effective device tailored for clinical settings.
- Defined specific parameters to quantify movement speed and regularity.
Main Results:
- The developed system effectively captures subtle changes in movement coordination.
- Quantifiable parameters for movement speed and regularity were established.
- The system provides objective data to aid in the early diagnosis and staging of neurological conditions.
Conclusions:
- An affordable and effective motion analysis system can significantly aid neurologists in early disease detection and patient management.
- Objective assessment of movement patterns offers a valuable tool for understanding disease progression.
- The defined movement parameters correlate with disease staging, facilitating clinical decision-making.

