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Related Experiment Videos

Partial volume effect in quantitative magnetic resonance perfusion imaging.

J J Chen1, M R Smith, R Frayne

  • 1Dept. of Electr. Eng. & Comput. Eng., Calgary Univ., Alta., Canada.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
Summary

Partial volume effect (PVE) in dynamic-susceptibility contrast (DSC) magnetic resonance (MR) perfusion imaging distorts the arterial input function (AIF). This distortion leads to inaccurate cerebral blood flow (CBF) calculations.

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Dynamic-susceptibility contrast (DSC) magnetic resonance (MR) perfusion imaging estimates cerebral blood flow (CBF) using deconvolution.
  • The accuracy of CBF estimation is susceptible to various distortions, notably the partial volume effect (PVE).

Purpose of the Study:

  • To investigate and quantify the bias in CBF estimation caused by PVE in DSC-MR perfusion imaging.
  • To highlight the impact of image spatial resolution on the reliability of perfusion parameters.

Main Methods:

  • Deconvolution of contrast concentration functions to obtain tissue residue functions.
  • Analysis of how PVE, arising from limited spatial resolution, affects the arterial input function (AIF).

Main Results:

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  • PVE significantly distorts the AIF when voxel size exceeds the arterial volume.
  • This AIF distortion directly results in miscalculated CBF values.
  • The study quantifies the degree of CBF estimation bias attributable to PVE.

Conclusions:

  • PVE is a critical experimental limitation in DSC-MR perfusion imaging.
  • Accurate CBF estimation is compromised by PVE, necessitating strategies to mitigate its effects.
  • Improving spatial resolution or developing PVE correction methods is crucial for reliable perfusion analysis.