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Related Experiment Video

Updated: Jul 17, 2026

Anaerobic Growth and Maintenance of Mammalian Cell Lines

Anaerobic Growth and Maintenance of Mammalian Cell Lines

Published on: July 21, 2018

Genetically enhanced growth causes increased mortality in hypoxic environments.

L Sundt-Hansen¹, L F Sundström, S Einum

¹Norwegian Institute for Nature Research, Tungasletta 2, 7485 Trondheim, Norway. line.sundt-hansen@nina.no

Biology Letters

|February 3, 2007

Summary

Fast-growing coho salmon (Oncorhynchus kisutch) genotypes show reduced survival under low oxygen (hypoxia). This suggests a trade-off between rapid growth and oxygen tolerance, potentially limiting rapid growth evolution across species.

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Area of Science:

Evolutionary biology
Aquatic ecology
Physiological ecology

Background:

Rapid growth in organisms is often linked to fitness benefits.
However, organisms typically grow slower than their maximum potential, indicating potential costs.
This study investigates the cost of rapid growth in terms of oxygen tolerance.

Purpose of the Study:

To test if rapid growth in coho salmon (Oncorhynchus kisutch) leads to reduced tolerance to low oxygen levels (hypoxia).
To compare survival and growth rates between wild and fast-growing transgenic coho salmon under hypoxic conditions.

Main Methods:

Coho salmon eggs from wild and transgenic genotypes were exposed to varying durations of hypoxia.
Survival and growth were monitored until the end of the larval stage.
Statistical analyses were performed to compare the effects of hypoxia on different genotypes.

Main Results:

Survival rates declined with increased hypoxia duration, with the most significant decrease observed in the transgenic (fast-growing) group.
Hypoxia negatively impacted larval mass in both groups.
Transgenic genotypes were larger than wild genotypes by the end of the larval stage, despite hypoxia.

Conclusions:

Fast-growing genotypes exhibit reduced tolerance to hypoxia, indicating a significant cost of rapid growth.
Oxygen availability may be a critical factor limiting the evolution of rapid growth across diverse taxa.
The findings highlight a potential evolutionary constraint on rapid growth strategies in aquatic organisms.