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Related Experiment Videos

Selenium level and cognitive function in rural elderly Chinese.

Sujuan Gao1, Yinlong Jin, Kathleen S Hall

  • 1Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA. sgao@iupui.edu

American Journal of Epidemiology
|February 3, 2007
PubMed
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Lifelong low selenium intake is linked to poorer cognitive function in older adults. This study found lower selenium levels in nails correlated with reduced performance on memory and cognitive tests.

Area of Science:

  • Nutritional Neuroscience
  • Trace Element Research
  • Geriatric Medicine

Background:

  • Selenium is a trace element with antioxidant properties, potentially protecting against free radical damage.
  • Previous research on selenium's impact on cognitive function and Alzheimer's disease has produced conflicting findings.
  • Understanding selenium's role in cognitive health is crucial for aging populations.

Purpose of the Study:

  • To investigate the association between lifelong selenium exposure and cognitive function in elderly Chinese individuals.
  • To determine if lower selenium levels correlate with impaired cognitive performance.

Main Methods:

  • A cross-sectional survey of 2,000 rural Chinese adults (≥65 years) was conducted.
  • Cognitive function was assessed using multiple standardized tests (dementia screening, word list learning, story recall, fluency, token test).

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  • Selenium content was analyzed in nail samples, and associations with cognitive scores were examined using analysis-of-covariance models.

    • Main Results:

    • Lower selenium levels in nail samples were significantly associated with lower scores across most cognitive tests (p < 0.0087).
    • A dose-response relationship was observed between selenium quintiles and cognitive performance.
    • The Animal Fluency Test did not show a significant association with selenium levels (p = 0.4378).

    Conclusions:

    • Findings in this geographically stable cohort suggest that lifelong low selenium levels are associated with diminished cognitive function.
    • This supports the hypothesis that adequate selenium intake may be important for maintaining cognitive health throughout life.
    • Further research is warranted to explore selenium's specific mechanisms in cognitive decline.