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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Antibody Actions01:26

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
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Related Experiment Video

Updated: Jul 17, 2026

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

Antibody and complement in transplant vasculopathy.

Jennifer Wehner1, Craig N Morrell, Taylor Reynolds

  • 1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.

Circulation Research
|February 3, 2007
PubMed
Summary

Antibodies and complement contribute to cardiac transplant vasculopathy by activating endothelial cells, platelets, and macrophages. Understanding these mechanisms is crucial for improving long-term cardiac allograft survival.

Related Experiment Videos

Last Updated: Jul 17, 2026

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

Area of Science:

  • Immunology
  • Cardiology
  • Transplantation

Background:

  • Coronary artery vasculopathy limits cardiac allograft survival despite advances in immunosuppression.
  • Transplant vasculopathy, or accelerated graft arteriosclerosis, shares features with arteriosclerosis but is specific to the graft.

Purpose of the Study:

  • To review the mechanisms by which antibodies and complement contribute to coronary vasculopathy in cardiac transplants.
  • To elucidate the synergistic roles of antibodies, complement, and inflammatory cells in graft arteriosclerosis.

Main Methods:

  • Review of existing literature on antibody and complement-mediated pathways in transplant vasculopathy.
  • Analysis of the pathogenic potential of combined antibody, complement, and inflammatory cell interactions.

Main Results:

  • Antibodies and complement independently and synergistically activate endothelial cells, platelets, and macrophages.
  • Combined stimulation of IgG and complement receptors enhances macrophage activation.
  • Antibodies and complement integrate key cellular components in transplant vasculopathy pathogenesis.

Conclusions:

  • Antibodies and complement play a significant role in the development of cardiac transplant vasculopathy.
  • Intra-graft production of antibodies and complement may contribute to vascular pathology.
  • The impact of current antibody-mediated rejection treatments on transplant vasculopathy remains unknown.