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Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Trihybrid Crosses02:27

Trihybrid Crosses

Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: Jul 17, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

[Genetic counseling in multiple pregnancies].

Sabine Uhrig1, Jochen B Geigl, Michael R Speicher

  • 1Institut fur Medizinische Biologie und Humangenetik, Medizinische Universitat Graz, Graz, Osterreich.

Gynakologisch-Geburtshilfliche Rundschau
|February 3, 2007
PubMed
Summary

Genetic counseling for multiple pregnancies presents unique challenges compared to singletons, especially with rising rates and advanced maternal age. Prenatal diagnosis and managing discordant anomalies require specialized approaches for twins and higher-order gestations.

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Related Experiment Videos

Last Updated: Jul 17, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Reproductive genetics
  • Maternal-fetal medicine
  • Clinical genetics

Context:

  • Multiple pregnancies are increasing, often linked to advanced maternal age and assisted reproductive technologies.
  • Prenatal diagnosis needs differ significantly between singleton and multiple gestations.
  • Distinguishing monozygotic from dizygotic twins impacts diagnostic sample collection.

Purpose:

  • To outline the distinct clinical, analytical, and ethical considerations in genetic counseling for multiple pregnancies.
  • To highlight challenges in prenatal diagnosis for twins and higher-order gestations.
  • To address the complexities of discordant anomalies in multiple births.

Summary:

  • Genetic counseling for multiple pregnancies differs substantially from singleton cases, necessitating tailored approaches.
  • The rising incidence of multiple births, particularly in older mothers and after ART, increases the demand for specialized prenatal genetic testing.
  • Unique issues arise, including sample collection strategies based on zygosity and managing discordant anomalies, even in monozygotic twins.

Impact:

  • Informs healthcare providers on best practices for genetic counseling in complex multiple pregnancies.
  • Aids in decision-making for invasive prenatal diagnostic procedures in diverse multiple gestation scenarios.
  • Contributes to improved patient care and ethical considerations in reproductive genetics for high-risk pregnancies.