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Tegaserod in constipation associated with Parkinson disease
1Movement Disorders Program, National Parkinson Foundation Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta, GA, USA. jmorgan@msg.edu
Clinical Neuropharmacology
|February 3, 2007
Summary
Tegaserod effectively treated constipation in Parkinson disease (PD) patients who did not respond to other therapies. This 5-hydroxytryptamine type 4 agonist improved bowel movement frequency and stool consistency, warranting further investigation.
Area of Science:
- Gastroenterology
- Neurology
- Pharmacology
Background:
- Constipation and impaired gastrointestinal motility are prevalent symptoms in Parkinson disease (PD).
- Standard treatments for constipation in PD patients often prove insufficient, necessitating alternative therapeutic strategies.
- Tegaserod, a 5-hydroxytryptamine type 4 agonist, is approved for chronic idiopathic constipation and enhances gastrointestinal motility.
Observation:
- This study evaluated the efficacy and tolerability of tegaserod in five patients experiencing constipation associated with Parkinson disease.
- Patients had persistent constipation despite undergoing various conventional interventions.
Findings:
- Tegaserod was generally well-tolerated among the observed Parkinson disease patients.
- The majority of patients experienced significant improvements in both the frequency of bowel movements and stool consistency.
Implications:
- Tegaserod demonstrates potential as a viable treatment option for managing constipation in Parkinson disease.
- Further clinical trials are recommended to confirm the efficacy and safety of tegaserod for PD-associated constipation.
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