Related Experiment Video

Updated: Jul 17, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice

Kenji Niwa1, Zenglin Lian, Kyoko Onogi

  • 1Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501-1194, Japan. kniwa@gifu-u.ac.jp

Oncology Reports
|February 3, 2007
PubMed

Insights

Glycyrrhizae radix (Gl radix) and its main component glycyrrhizin (GL) show promise in preventing endometrial cancer. These compounds significantly reduced cancer incidence and key inflammatory markers in a mouse model.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products

Background:

  • Endometrial cancer is a significant health concern.
  • Estradiol (E2) plays a role in endometrial carcinogenesis.
  • Glycyrrhizae radix (Gl radix) has shown prior inhibitory effects on endometrial carcinogenesis.

Purpose of the Study:

  • To clarify the effects of Gl radix and glycyrrhizin (GL) on E2-related endometrial carcinogenesis.
  • To investigate the molecular mechanisms underlying the preventive effects of Gl radix and GL.

Main Methods:

  • Mouse models of endometrial carcinogenesis were utilized.
  • The effects of Gl radix and GL on COX-2, IL-1alpha, and TNF-alpha mRNA expression were assessed.
  • The incidence of endometrial adenocarcinoma was evaluated.

Main Results:

  • Both Gl radix and GL significantly decreased COX-2, IL-1alpha, and TNF-alpha mRNA expression.
  • GL treatment resulted in a significant decrease in endometrial adenocarcinoma incidence.
  • The findings suggest GL is responsible for the preventive effects of Gl radix.

Conclusions:

  • Glycyrrhizae radix and glycyrrhizin demonstrate chemopreventive potential against endometrial cancer.
  • The mechanism involves the suppression of COX-2, IL-1alpha, and TNF-alpha.
  • Gl radix and GL are promising candidates for human endometrial cancer chemoprevention.

More Related Videos

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue08:02

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

Published on: January 6, 2012

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence08:02

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...