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Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on

Gary D Kruh1, Martin G Belinsky, James M Gallo

  • 1Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. GD_Kruh@fccc.edu

Cancer Metastasis Reviews
|February 3, 2007
PubMed

Insights

Mice lacking Mrp2, Mrp3, and Mrp4 transporters offer new insights into their roles. Investigations of these gene-disrupted models reveal physiological and pharmacological functions of these important drug transporters.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Genetics

Background:

  • The Multidrug Resistance-associated Protein (MRP) family comprises nine transporters.
  • At least eight MRP transporters are lipophilic anion transporters.
  • These transporters can confer resistance to various anticancer agents.

Purpose of the Study:

  • To review insights into the physiological and pharmacological functions of Mrp2, Mrp3, and Mrp4.
  • To discuss findings from investigations using newly developed gene-disrupted mouse models for Mrp2, Mrp3, and Mrp4.

Main Methods:

  • Utilizing gene-disrupted mouse models for Mrp2, Mrp3, and Mrp4.
  • Reviewing existing literature and research findings related to these models.

Main Results:

  • Gene disruptions in Mrp2, Mrp3, and Mrp4 have been successfully created in mice.
  • Investigations using these models provide valuable data on transporter functions.

Conclusions:

  • New mouse models for Mrp2, Mrp3, and Mrp4 are crucial tools for understanding their roles.
  • These models enhance our knowledge of drug transport and resistance mechanisms.

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