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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

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[Infusion pumps and patient safety].

Brian Bjørn¹, Kim Garde, Beth Lilja Pedersen

¹Hvidovre Hospital, Enhed for Patientsikkerhed, Afsnit 423.

Ugeskrift for Laeger

|February 6, 2007

Summary

Infusion pump safety is enhanced by standardized procurement and usability testing. User errors cause most critical incidents, highlighting the need for better training and user-friendly device design.

Area of Science:

Medical device safety
Clinical engineering
Healthcare technology management

Context:

Infusion pumps are vital for precise medication delivery but pose patient safety risks.
Potential hazards include free-flow, inadequate staff training, and device limitations.
Analysis of technical and organizational data from Copenhagen Hospital Corporation (CHC) was conducted.

Purpose:

To analyze critical incidents related to infusion pump use in CHC hospitals.
To identify causes of infusion pump-related errors and patient safety risks.
To recommend improvements for infusion pump procurement and usage.

Summary:

Forty-two different infusion pump models are used across five CHC hospitals.
71% of 919 volumetric infusion pumps feature set-based free-flow protection.

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User error, primarily incorrect infusion rate setting, caused 40% of critical incidents.

Infusion line disconnection or kinking led to 27% of incident reports, including two cases of awareness under anesthesia.

Impact:

Centralized procurement and standardized equipment libraries can mitigate patient safety risks.
Mandatory usability testing using validated methods before procurement is crucial.
Further research into user-friendly medical equipment design is necessary to improve safety and reduce under-use.