Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultra-High-Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Spectroscopic Techniques in Bacterial Analysis: Applications of FTIR and Raman-Review.

Foods (Basel, Switzerland)·2026
Same author

Early-life maternal probiotic supplementation programs sex- and region-specific gene expression in the adult offspring brain.

Brain, behavior, & immunity - health·2026
Same author

Electro-interactions: A review of the effects of electric fields on bacterial cells.

Biotechnology advances·2025
Same author

The Role of the Metal-Ion Charge in Mineral Interface Doping.

ACS applied materials & interfaces·2025
Same author

Sex-Specific Long-Term Effects of Perinatal Limosilactobacillus reuteri on Social Cognition, Gene Expression, and Gut Microbiota.

Journal of neurochemistry·2025

Related Experiment Video

Updated: Jul 17, 2026

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
10:08

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture

Published on: October 21, 2009

Electrospun aliphatic polycarbonates as tailored tissue scaffold materials.

Alexander Welle1, Mario Kröger, Manfred Döring

  • 1Forschungszentrum Karlsruhe, Institute for Biological Interfaces (IBG), P.O. Box 3640, 76021 Karlsruhe, Germany. alexander.welle@imb.fzk.de

Biomaterials
|February 6, 2007
PubMed
Summary

Two novel aliphatic polycarbonates, poly(propyl carbonate) (PPC) and poly(cyclohexyl carbonate) (PCHC), were synthesized. PPC nanofibres exhibited controlled biodegradation and supported excellent cell adhesion and viability for L929 fibroblasts and primary rat hepatocytes.

More Related Videos

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells
08:03

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

Published on: June 18, 2014

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications
12:28

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

Related Experiment Videos

Last Updated: Jul 17, 2026

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
10:08

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture

Published on: October 21, 2009

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells
08:03

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

Published on: June 18, 2014

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications
12:28

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials Engineering

Background:

  • Aliphatic polycarbonates offer tunable properties for biomedical applications.
  • Controlled synthesis and modification of polymer nanostructures are crucial for advanced biomaterials.
  • Photochemical modifications present a novel approach for tailoring polymer surface and bulk characteristics.

Purpose of the Study:

  • To synthesize and characterize two distinct aliphatic polycarbonates: poly(propyl carbonate) (PPC) and poly(cyclohexyl carbonate) (PCHC).
  • To investigate the effects of deep UV irradiation on the surface and bulk properties of PPC nanofibres.
  • To evaluate the potential of PPC nanofibres as scaffolds for cell culture, specifically for L929 fibroblasts and primary rat hepatocytes.

Main Methods:

  • Heterogeneous catalysis using zinc glutarate for PPC synthesis.
  • Homogeneous catalysis via a zinc acetate complex for PCHC synthesis and living copolymerization.
  • Electrospinning technique to fabricate PPC and PCHC nanofibres.
  • Low-power deep UV irradiation for photochemical surface and bulk modifications.
  • Plasma protein adsorption assays.
  • Cell culture experiments with L929 fibroblasts and primary rat hepatocytes.

Main Results:

  • Well-defined PPC and PCHC nanofibres with porous surfaces were successfully synthesized.
  • Deep UV irradiation induced significant changes in both surface and bulk properties of PPC nanofibres.
  • Photochemical modifications altered plasma protein adsorption on both polymer surfaces.
  • First-time observation of photochemical bulk modifications in PPC nanofibres, enabling spatial control over biodegradation rates.
  • PPC nanofibres demonstrated excellent biocompatibility, supporting high adhesion and viability of L929 fibroblasts and primary rat hepatocytes.

Conclusions:

  • The synthesized aliphatic polycarbonates, PPC and PCHC, are promising materials for biomedical applications.
  • Photochemical modifications offer a versatile tool for tailoring the properties of PPC nanofibres, including controlled biodegradation.
  • PPC nanofibres serve as effective scaffolds for cell culture, promoting cell adhesion and viability, indicating their potential for tissue engineering and regenerative medicine.