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Anti-diarrheal activity of methanol extract of Litsea polyantha bark in mice
Brijendra Singh Poonia1, D Sasmal, P M Mazumdar
1Division of Pharmacology, Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi (J.H.), India. biju_poonia@rediffmail.com
Fitoterapia
|February 6, 2007
Abstract:
The anti-diarrheal activity of methanol extract of dried bark and aerial parts of Litsea polyantha (MELP) has been evaluated in mice using different models (castor oil-induced diarrhea and propulsive gut motility in mice). MELP (50, 75, 100 mg/kg, p.o.) significantly (P<0.01) reduced the onset of diarrhea, fecal excretion and also showed a significant (P<0.001) reduction in gastrointestinal motility on charcoal meal test in mice. The results of the study support the folklore use of the plant for diarrheal remedies.