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Updated: Jul 17, 2026

Establishment of an Extracellular Acidic pH Culture System
Published on: November 19, 2017
Metabolic alkalosis, bedside and bench
Melvin E Laski1, Sandra Sabatini
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79413, USA. melvin.laski@ttuhsc.edu
Abstract:
Although significant contributions to the understanding of metabolic alkalosis have been made recently, much of our knowledge rests on data from clearance studies performed in humans and animals many years ago. This article reviews the contributions of these studies, as well as more recent work relating to the control of renal acid-base transport by mineralocorticoid hormones, angiotensin, endothelin, nitric oxide, and potassium balance. Finally, clinical aspects of metabolic alkalosis are considered.
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