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Retrograde ejaculation: successful treatment with artificial insemination
P J van der Linden1, P M Nan, E R te Velde
1Department of Obstetrics and Gynecology, Academic Hospital, State University Utrecht, The Netherlands.
Obstetrics and Gynecology
|January 1, 1992
Summary
This study shows that sperm retrieved from urine can successfully treat infertility caused by retrograde ejaculation. This method achieved a 44.4% pregnancy rate per cycle, offering hope for affected couples.
Area of Science:
- Reproductive Medicine
- Urology
Background:
- Retrograde ejaculation, characterized by low or absent sperm in ejaculate, stems from internal sphincter dysfunction.
- This condition often leads to infertility in affected couples.
Purpose of the Study:
- To evaluate the efficacy of intrauterine insemination (IUI) with spermatozoa retrieved from urine in couples experiencing infertility due to retrograde ejaculation.
Main Methods:
- Eight couples with infertility from retrograde ejaculation were treated over nearly three years.
- Spermatozoa were collected from urine samples, processed using Percoll gradients and washing procedures.
- Ovulation was monitored using blood Luteinizing Hormone (LH) levels, and insemination was performed via IUI.
Main Results:
- Twelve pregnancies were achieved in eight couples, with a pregnancy rate of 44.4% per cycle.
- Seven couples achieved pregnancy within three cycles.
- Five healthy infants were born, four pregnancies resulted in spontaneous abortion, and three were ongoing.
Conclusions:
- Spermatozoa obtained from urine can be successfully used for intrauterine insemination to treat retrograde ejaculation-related infertility.
- Proper collection of urine-semen samples in a buffered medium and precise timing of insemination based on LH surge are crucial for treatment success.