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Updated: Jul 17, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute renal injury and dysfunction following elective abdominal aortic surgery
M Tallgren1, T Niemi, R Pöyhiä
1Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. minna.tallgren@hus.fi
Summary
Most patients undergoing open abdominal aortic surgery experience kidney injury, with 22% developing acute renal dysfunction (ARD). Intraoperative hypotension and low cardiac output are key risk factors for ARD.
Area of Science:
- Nephrology
- Cardiovascular Surgery
- Critical Care Medicine
Background:
- Open abdominal aortic surgery poses significant risks to renal function.
- Kidney injury and acute renal dysfunction (ARD) are known complications.
- Identifying risk factors is crucial for perioperative management.
Purpose of the Study:
- To determine the incidence of kidney injury and ARD after open abdominal aortic surgery.
- To identify associated risk factors for ARD in this patient population.
Main Methods:
- Prospective study of 69 patients undergoing elective infrarenal aortic repair.
- Standardized anesthesia and hemodynamic management targeting specific physiological parameters.
- Measurement of urinary albumin-creatinine and N-acetyl-B-D-glucosaminidase-creatinine ratios; ARD defined by RIFLE criteria.
Main Results:
- Kidney injury observed in the majority of patients.
- ARD developed in 22% of patients; 4% experienced acute renal failure.
- ARD associated with older age, lower pre-operative GFR, intraoperative hypotension, low cardiac index, rhabdomyolysis, and reoperation.
Conclusions:
- Kidney injury is common in infrarenal aortic surgery patients.
- Acute renal dysfunction affects 22%, with hypotension and low cardiac output as modifiable risk factors.
- Optimizing perioperative management can potentially reduce ARD incidence.
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