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Updated: Jul 17, 2026

Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Stress and wound healing.

Loretta Vileikyte¹

¹Department of Medicine, University of Manchester, Manchester, UK. lvileikyte@med.miami.edu

Clinics in Dermatology

|February 6, 2007

Summary

Stress disrupts neuroendocrine immune balance, delaying wound healing, particularly in acute injuries. Further research is needed on stress and chronic wound healing, such as diabetic foot ulcers.

Area of Science:

Neuroendocrinology
Immunology
Wound Healing Research

Background:

Stress disrupts neuroendocrine immune equilibrium, negatively impacting health.
Strong evidence links stress to delayed wound repair, especially in acute wounds.
Cortisol elevation down-regulates inflammatory response, hindering healing.

Purpose of the Study:

Investigate the impact of stress on wound healing.
Identify cellular mechanisms linking stress and wound repair.
Highlight the need for studies on stress and chronic wound healing.

Main Methods:

Review of murine and human studies on stress and acute wound healing.
Analysis of cellular and molecular mechanisms involved.
Identification of knowledge gaps regarding chronic wounds.

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Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

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Last Updated: Jul 17, 2026

Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Main Results:

Stress, via elevated cortisol, delays acute wound healing.
Specific cellular pathways linking stress to impaired wound repair identified.
Limited research exists on stress and chronic wound healing.

Conclusions:

Stress significantly impairs acute wound healing through neuroendocrine-immune pathways.
Findings from acute wounds may not directly apply to chronic wounds.
Further investigation into stress and chronic wound healing, like diabetic foot ulcers, is crucial.