Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Healing I: Introduction

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2026

Same author

The 4E-BP1 deletion modestly mitigates mTORC1-deficient epidermal barrier defects.

JID innovations : skin science from molecules to population health·2026

Same author

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways.

bioRxiv : the preprint server for biology·2026

Same author

Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H<sub>2</sub>S in biological samples.

Nature communications·2025

Same author

Correction: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning.

Basic research in cardiology·2025

Same author

Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.

Nature·2025

Search research articles

Related Experiment Video

Updated: Jul 17, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Gene therapy and wound healing.

Sabine A Eming¹, Thomas Krieg, Jeffrey M Davidson

¹Department of Dermatology, University of Cologne, D-50937 Cologne, Germany.

Clinics in Dermatology

|February 6, 2007

Summary

Gene therapy offers a novel approach to wound healing by using genetically modified cells to deliver growth factors. This method aims to improve therapeutic strategies beyond traditional recombinant protein application.

Area of Science:

Regenerative Medicine
Molecular Biology
Tissue Engineering

Background:

Wound repair is a complex biological process involving cellular and molecular interactions.
Recent advances have illuminated signals controlling cell behavior during healing.
Novel therapeutic strategies, particularly growth factor delivery, are under investigation.

Purpose of the Study:

To review the molecular and cellular basis of wound repair mechanisms.
To explore the challenges and successes of growth factor delivery in wound healing.
To provide an overview of gene transfer techniques for tissue repair.

Main Methods:

Literature review of wound repair mechanisms.
Analysis of therapeutic strategies involving growth factor delivery.

More Related Videos

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

Related Experiment Videos

Last Updated: Jul 17, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

Examination of gene transfer techniques and studies in tissue repair.

Main Results:

Effective delivery of growth factors is critical for successful wound healing strategies.
Topical application of recombinant growth factors has limitations.
Genetically modified cells offer a regulated delivery system for growth factors.

Conclusions:

Gene transfer presents a promising molecular approach to enhance wound healing.
Understanding cellular and molecular repair mechanisms is key to developing new therapies.
Further research into gene therapy for tissue repair is warranted.