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Published on: August 15, 2025
[Mandibular chloroma]
1Service de chirurgie maxillofaciale et stomatologie du Professeur Compère, CHU Côte de Nacre, 14033 Caen cedex, France.
Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|February 6, 2007
Summary
A rare case of granulocytic monoblastic sarcoma, also known as chloroma, presented as a mandibular tumor in a young woman. Early diagnosis and chemotherapy led to a complete cure, highlighting the importance of prompt treatment for this leukemia-associated condition.
Area of Science:
- Oncology
- Hematology
- Radiology
Background:
- Granulocytic monoblastic sarcoma (chloroma) is a rare extramedullary tumor composed of immature granulocytes, often associated with or preceding leukemia.
- Mandibular involvement by chloroma is exceptionally uncommon, presenting diagnostic challenges.
Observation:
- A 23-year-old female presented with facial swelling involving the mandible.
- Radiographic imaging revealed an osteolytic lesion in the mandibular angle, with CT scans showing cortical bone rupture and soft tissue extension.
- Biopsy confirmed the diagnosis of granulocytic monoblastic sarcoma.
Findings:
- The patient was diagnosed with granulocytic monoblastic sarcoma manifesting as a mandibular tumor.
- The condition was effectively treated with high-dose chemotherapy.
Implications:
- This case underscores the rarity of mandibular chloroma and the importance of early diagnosis for effective treatment.
- Prompt identification and intervention, including high-dose chemotherapy, can lead to complete remission in cases of leukemia-associated chloroma.
