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[Mandibular chloroma].

B Rysanek1, J Nicolas, T Alix

  • 1Service de chirurgie maxillofaciale et stomatologie du Professeur Compère, CHU Côte de Nacre, 14033 Caen cedex, France.

Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|February 6, 2007
PubMed
Summary
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A rare case of granulocytic monoblastic sarcoma, also known as chloroma, presented as a mandibular tumor in a young woman. Early diagnosis and chemotherapy led to a complete cure, highlighting the importance of prompt treatment for this leukemia-associated condition.

Area of Science:

  • Oncology
  • Hematology
  • Radiology

Background:

  • Granulocytic monoblastic sarcoma (chloroma) is a rare extramedullary tumor composed of immature granulocytes, often associated with or preceding leukemia.
  • Mandibular involvement by chloroma is exceptionally uncommon, presenting diagnostic challenges.

Observation:

  • A 23-year-old female presented with facial swelling involving the mandible.
  • Radiographic imaging revealed an osteolytic lesion in the mandibular angle, with CT scans showing cortical bone rupture and soft tissue extension.
  • Biopsy confirmed the diagnosis of granulocytic monoblastic sarcoma.

Findings:

  • The patient was diagnosed with granulocytic monoblastic sarcoma manifesting as a mandibular tumor.
  • The condition was effectively treated with high-dose chemotherapy.

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Implications:

  • This case underscores the rarity of mandibular chloroma and the importance of early diagnosis for effective treatment.
  • Prompt identification and intervention, including high-dose chemotherapy, can lead to complete remission in cases of leukemia-associated chloroma.