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Updated: Jul 17, 2026

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
Published on: May 23, 2025
Patients' attitudes to Helicobacter pylori breath and stool antigen tests compared to blood serology
Cliodna A M McNulty1, Jillian W Whiting
1Health Protection Agency Primary Care Unit, Microbiology Department Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK. cliodna.mcnulty@hpa.org.uk
Background:
The National Institute for Health and Clinical Excellence (NICE) recommends that patients with uninvestigated dyspepsia, unresponsive to proton pump inhibitors, should be tested for Helicobacter pylori using a stool antigen or urea breath test rather than blood-based serology.
Objective:
To determine if a stool antigen or urea breath test is acceptable to patients.
Method:
Satisfaction questionnaire circulated to all primary care patients who had blood serology for H. pylori between January and July 2004.
Results:
Four hundred and sixty-two out of 717 Gloucestershire patients returned the questionnaire. Three-quarters of respondents stated that they would be willing to provide a stool or breath H. pylori test if they were told they were more accurate than the blood test. If the blood test was not available, 58% stated they would prefer the breath test and 34% the stool test. When patients were not given an explanation for the transfer to the new tests, only 11% stated they would prefer to provide a stool and 19% the breath test. 80% required an extra appointment for their blood test.
Conclusion:
The majority of patients would be happy to provide a stool sample or breath test provided they are made aware that these tests are more accurate than blood serology.
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