Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enhancer identification through comparative genomics.

Axel Visel1, James Bristow, Len A Pennacchio

  • 1Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Seminars in Cell & Developmental Biology
|February 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional annotation of non-coding variants identifies a novel enhancer with activity in neural crest cell-derived lineages.

Research square·2026
Same author

Non-coding structural variants disrupt FOXG1 transcriptional regulation in early neurodevelopment.

Nature communications·2026
Same author

Cis-regulatory evolution shapes facial diversity in birds and mammals.

Science advances·2026
Same author

Multiomics and deep learning dissect regulatory syntax in human development.

Nature·2026
Same author

Enhancers that direct gene expression to central nervous system vascular endothelial cells in vivo.

Neuron·2026
Same author

Multi-season analysis reveals hundreds of drought-responsive genes in sorghum.

The Plant journal : for cell and molecular biology·2026
Same journal

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same journal

Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling.

Seminars in cell & developmental biology·2026
Same journal

Chemical biology tools for studying tissue development.

Seminars in cell & developmental biology·2026
Same journal

Tetrahymena as a model organism for cilia research.

Seminars in cell & developmental biology·2026
Same journal

Emerging Concepts in Cardiovascular Development and Regeneration.

Seminars in cell & developmental biology·2026
Same journal

Endothelial origin of hematopoietic stem cells: Insights from new technologies and unresolved questions.

Seminars in cell & developmental biology·2026
See all related articles

Comparative genomics revolutionizes gene regulatory element identification by prioritizing conserved sequences. This approach enhances biological hypothesis generation, especially for cardiac-related genes.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Genomic sequence availability enables new methods for identifying gene regulatory elements.
  • Traditional methods involved random scanning of genomic fragments, which is less efficient.
  • Comparative genomics utilizes evolutionary conservation to prioritize functional sequences.

Purpose of the Study:

  • To highlight the paradigm shift in identifying distant-acting gene regulatory elements using comparative genomics.
  • To discuss the challenges and considerations in applying comparative genomic approaches.
  • To emphasize the potential benefits for identifying cardiac-related gene enhancers.

Main Methods:

  • Utilizing publicly available comparative sequence datasets.
  • Electronically prioritizing putative functional sequences based on evolutionary conservation.

Related Experiment Videos

  • Dynamically considering species and comparison methods based on biological questions.

    • Main Results:

    • Comparative genomics provides prioritized lists of potential functional sequences.
    • This approach significantly increases the power of biological hypothesis generation.
    • Challenges remain in the application, requiring careful consideration of methods and species.

    Conclusions:

    • Comparative genomic approaches offer a powerful, albeit complex, tool for discovering gene regulatory elements.
    • The methodology is particularly promising for identifying distant-acting transcriptional enhancers of cardiac-related genes.
    • Appropriate application of these techniques exponentially enhances biological discovery potential.