Related Experiment Videos

Deep vein thrombosis with Staphylococcus aureus septicemia

Rajniti Prasad1, O P Mishra, Pragya Pant

  • 1Department of Pediatrics, Institute of Medical Sciences, BHU, Varanasi, India. rajnitip@yahoo.co.in

Indian Pediatrics
|February 6, 2007
PubMed

Insights

Deep vein thrombosis (DVT) in children can occur with staphylococcal septicemia. Early antibiotics and anticoagulation therapy improved survival in three of four pediatric cases.

Area of Science:

  • Pediatric Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Deep vein thrombosis (DVT) in children is multifactorial, often linked to hypercoagulable states, immobility, or central venous catheters.
  • Staphylococcal septicemia is a serious bloodstream infection that can lead to severe complications.

Observation:

  • This case series reports on four pediatric patients diagnosed with deep vein thrombosis (DVT).
  • All four children presented with culture-proven staphylococcal septicemia.

Findings:

  • Deep vein thrombosis (DVT) was observed in children experiencing staphylococcal septicemia.
  • One child with DVT and staphylococcal septicemia unfortunately died.
  • The remaining three children survived after receiving appropriate antibiotic and anticoagulation treatments.

Implications:

  • Staphylococcal septicemia should be considered a potential risk factor for deep vein thrombosis (DVT) in pediatric patients.
  • Prompt diagnosis and management, including antibiotics and anticoagulation, are crucial for improving outcomes in children with DVT and septicemia.
  • This highlights the importance of vigilance for thrombotic events in critically ill children with infections.

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...