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Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
Abdullah H Alsaghir1, Abdullah F Al-Mobeireek, Hamdan Al-Jahdali
1Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Annals of Saudi Medicine
|February 6, 2007
Summary
This study reviews bronchiolitis obliterans organizing pneumonia (BOOP) cases in the Middle East, finding it presents like pneumonia and usually has a good outcome with steroids, though underlying conditions can worsen prognosis.
Area of Science:
- Pulmonology
- Pathology
- Radiology
Background:
- Limited data on bronchiolitis obliterans organizing pneumonia (BOOP) in the Middle East.
- Need to characterize clinical features and outcomes of BOOP in this region.
Purpose of the Study:
- To retrospectively review histopathologically proven cases of BOOP.
- To describe the clinical presentation, radiographic findings, and outcomes of BOOP in Riyadh.
Main Methods:
- Retrospective chart review of BOOP/cryptogenic organizing pneumonia (COP) cases over 10 years.
- Inclusion criteria: histological proof of BOOP with compatible clinical picture.
- Review of chest radiographs and high-resolution CT scans.
Main Results:
- Twenty biopsy-proven BOOP cases identified (11 males, 9 females; mean age 58).
- Common symptoms: cough (85%), fever (70%), dyspnea (85%); typical radiographic pattern: bilateral alveolar infiltrate.
- Restrictive pattern on pulmonary function tests (11/14 patients). Idiopathic BOOP in 70%; associations include thyroid cancer, rheumatoid arthritis.
- 50% complete response to steroids; 30% partial response. 15.8% with secondary BOOP died due to respiratory failure.
Conclusions:
- Clinical presentation of BOOP in this series is similar to international reports.
- Majority of patients experience favorable outcomes, especially with steroid treatment.
- Underlying conditions can be associated with a poorer prognosis in BOOP.
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