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Published on: May 31, 2024
Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection
F B Aggio1, M E Farah, G B de Melo
1Vision Institute, Federal University of São Paulo, São Paulo, Brazil.
Purpose:
To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.
Methods:
Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later. Vitreous samples were obtained, followed by the injection of vancomycin 1 mg/0.1 ml and ceftazidime 2.25 mg/0.1 ml. Pulsed-field gel electrophoresis (PFGE) was used to determine whether the isolated microorganisms were the same.
Results:
Coagulase-negative staphylococci were identified and isolated from the vitreous specimen of both patients. PFGE revealed different patterns of banding, excluding that interpatient contamination occured.
Conclusions:
Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.
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