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Updated: Jul 17, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
Sudden-onset blindness in sickle cell disease due to retinal artery occlusion
Robert I Liem1, Diane M Calamaras, Manpreet S Chhabra
1Division of Hematology, Oncology and Stem Cell Transplant, Children's Memorial Hospital, Chicago, Illinois, USA. rliem@childrensmemorial.org
Abstract:
Central retinal artery occlusion (CRAO) is a rare and potentially devastating cause of acute blindness in sickle cell disease (SCD) that is unique compared to classic sickle retinopathy. Few details related to this complication in SCD are known, including its risk factors, pathogenesis, presentation, treatment and outcomes. We present three patients with SCD and retinal artery occlusion. The overall variability in clinical presentation, treatment and prognosis reported in the literature underscores the need for a greater understanding of these factors as they relate to this complication in SCD.
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