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Recurrent Henoch-Schönlein purpura in children

Dario Prais1, Jacob Amir, Moshe Nussinovitch

  • 1Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. dariop@clalit.org.il

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|February 7, 2007
PubMed

Insights

Recurrent Henoch-Schönlein purpura (HSP) in children is uncommon, with no clear predictors for recurrence. Second episodes may be longer, but prognosis remains good.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Immunology

Background:

  • Henoch-Schönlein purpura (HSP), or anaphylactoid purpura, is a systemic vasculitis primarily affecting children aged 3-10 years.
  • Recurrent episodes of HSP, while not common, warrant investigation into associated clinical and epidemiological factors.

Purpose of the Study:

  • To characterize the clinical, epidemiological, and laboratory findings in pediatric patients experiencing recurrent Henoch-Schönlein purpura.
  • To identify potential predictors for HSP recurrence in a hospitalized pediatric cohort.

Main Methods:

  • Retrospective analysis of medical records for children hospitalized with HSP between 1969 and 2004.
  • Comparison of demographic and clinical characteristics between patients with single and recurrent HSP episodes.

Main Results:

  • Out of 260 children hospitalized for HSP, only 7 (2.7%) experienced recurrence.
  • No significant differences in demographics or clinical presentation were found between single and recurrent HSP cases.
  • The second HSP episode was longer than the first, with a mean interval of 13.5 months between episodes.

Conclusions:

  • No clinical or laboratory factors reliably predicted recurrent Henoch-Schönlein purpura in this inpatient pediatric population.
  • Recurrent HSP episodes can be prolonged, and the interval between episodes may be longer than previously reported.
  • Despite recurrence, Henoch-Schönlein purpura generally has a favorable prognosis in hospitalized children.
Abstract

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