Peritoneal hemorrhage due to a ruptured ovarian cyst in ITP
Joel Kaplan1, Christine C Bannon, Michael Hulse
1Pennsylvania State University, Milton S. Hershey Medical Center, PO Box 850, Hershey, PA, USA.
Insights
Immune thrombocytopenic purpura (ITP) rarely causes severe bleeding in children. This case highlights a rare severe intra-abdominal bleed in an adolescent female with EBV-associated ITP.
Area of Science:
- Pediatric Hematology
- Immunology
- Viral Infections
Background:
- Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by low platelet counts.
- While ITP in children typically has a low risk of severe bleeding, adolescent females present unique risks.
- Epstein-Barr virus (EBV) associated ITP generally follows a similar course to non-EBV ITP.
Observation:
- This report details an 18-year-old female diagnosed with EBV-associated ITP.
- The patient experienced a severe intra-abdominal hemorrhage.
- The hemorrhage was attributed to a hemorrhagic ovarian cyst.
Findings:
- EBV-associated ITP in adolescents, though rare, can lead to severe, unexpected bleeding complications.
- Hemorrhagic ovarian cysts represent a potential, serious complication in young females with ITP.
- The case underscores the need for vigilance regarding gynecological complications in adolescent females with ITP.
Implications:
- Adolescent females with ITP require careful monitoring for gynecological and other severe bleeding risks.
- Early recognition and management of complications like hemorrhagic ovarian cysts are crucial.
- This case expands understanding of the potential severity and unique presentations of ITP in adolescent females.
Abstract:
Immune thrombocytopenic purpura in children rarely causes severe bleeding. The incidence of intracranial hemorrhage is approximately 0.2% to 1.0%, and severe bleeding (defined as persistent epistaxis, melena, menorrhagia, gastrointestinal bleeding, etc, requiring hospitalization or transfusion) occurs in only 5% of patients. Epstein-Barr virus (EBV) associated idiopathic thrombocytopenic purpura (ITP) tends to behave similarly to non-EBV - associated ITP with no increase in hemorrhagic complications and only a small increase in time to remission. Immune thrombocytopenic purpura diagnosed in adolescence is more likely to be chronic then in childhood ITP, but has a higher rate of spontaneous resolution than in adults. However, females in this age group are in their early childbearing years and present a unique set of possible hemorrhagic complications not seen in younger patients. We present the case of an 18-year-old female with EBV-associated ITP, who developed a severe intra-abdominal bleed secondary to a hemorrhagic ovarian cyst.
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