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Onyx: a unique neuroembolic agent.

Michael Ayad¹, Eric Eskioglu, Robert A Mericle

¹Vanderbilt University, Department of Neurological Surgery, Vanderbilt University Medical Center, MCN T-4224, Nashville, TN 37212, USA. michael.ayad@vanderbilt.edu

Expert Review of Medical Devices

|February 7, 2007

Summary

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Cerebral arteriovenous malformations (AVMs) pose risks of hemorrhage. Onyx, an ethylene vinyl alcohol copolymer, is a new embolic agent offering potential advantages for endovascular embolization in treating brain AVMs.

Area of Science:

Neurology
Interventional Radiology
Biomaterials Science

Background:

Cerebral arteriovenous malformations (AVMs) can cause life-threatening hemorrhage.
Current embolic agents have limitations like recanalization and handling issues.

Purpose of the Study:

To evaluate Onyx, an ethylene vinyl alcohol copolymer, as an embolic agent for cerebral AVMs.
To compare Onyx with existing embolic agents for endovascular treatment.

Main Methods:

Onyx, an ethylene vinyl alcohol copolymer, was approved by the US FDA in July 2005.
It is used as an embolic agent for brain arteriovenous malformations.

Main Results:

Onyx appears to offer advantages over other embolic agents.

Related Experiment Videos

Long-term follow-up data for Onyx is currently limited.

Conclusions:

Onyx represents a promising option for the endovascular management of cerebral AVMs.
Further long-term studies are needed to fully assess its efficacy and safety.