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Functional site analysis in proteins of g protein signaling pathways using fuzzy evolutionary trace method
Zhang Fan1, Liu Zhicheng, Li Xia
1Department of Bioinformatics, Capital University of Medical Sciences.
Abstract:
GPCRs are physiologically significant receptors linked to numerous diseases including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the interactions upon which G protein signaling pathways are built. Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.
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