Related Experiment Video
Updated: Jun 18, 2026

11:07
In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves
Published on: April 13, 2014
Function electrical stimulation signals generator circuits for the central nerve and the sciatic nerve
Li Wenyuan1, Zhang Zhenyu, Wang Zhi-Gong
1Institute of RF- & OE-ICs, Southeast University, 210096 Nanjing, China.
Summary
New functional electrical stimulation (FES) circuits were developed using discrete components for central and sciatic nerve stimulation. These circuits offer adjustable gain and bandwidth, delivering precise current or voltage signals via microelectrodes.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Electrical Engineering
Background:
- Functional electrical stimulation (FES) is crucial for restoring function after nerve damage.
- Existing FES systems often require complex circuitry or lack adaptability.
- Targeted nerve stimulation necessitates precise signal generation tailored to specific nerve types.
Purpose of the Study:
- To design and implement novel FES circuits for both central and sciatic nerve stimulation.
- To achieve high performance characteristics, including variable gain and wide bandwidth.
- To ensure compatibility with different microelectrode types for versatile application.
Main Methods:
- Designed FES signal generation circuits using discrete operational amplifiers.
- Implemented circuits with variable gain (20-60 dB) and bandwidth exceeding 10 kHz.
- Utilized shaft microelectrodes for central nerve stimulation and cuff microelectrodes for sciatic nerve stimulation.
Main Results:
- The central nerve stimulation circuit provides a current signal >1 mA into a kilo-ohm load.
- The sciatic nerve stimulation circuit delivers a voltage signal >10 Vs into a kilo-ohm load.
- Both circuits demonstrate robust performance with microelectrode loads.
Conclusions:
- The developed discrete FES circuits effectively generate precise stimulation signals for central and sciatic nerves.
- The adaptable gain and bandwidth make these circuits suitable for various FES applications.
- These circuits represent a significant advancement in accessible and effective neurostimulation technology.

