Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Functions of the Nervous System

Functions of the Nervous System

The nervous system is responsible for coordinating and regulating the body's functions. It functions through three main processes: sensory, integrative, and motor processes. Sensory function involves the detection and transmission of information about internal and external stimuli from sensory receptors to the CNS. The CNS processes this information through an integrative function, where it interprets and makes decisions based on the incoming sensory information. Finally, the motor function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Late-onset anti-Yo antibody-positive paraneoplastic cerebellar degeneration: a case report.

Frontiers in surgery·2026

Same author

Mapping the landscape: A bibliometric perspective on autophagy in spinal cord injury.

Medicine·2024

Same author

Effect of autologous fat transfer in acute burn wound management: A randomized controlled study.

Burns : journal of the International Society for Burn Injuries·2023

Same author

Social Entrepreneurship Orientation and Enterprise Fortune: An Intermediary Role of Social Performance.

Frontiers in psychology·2022

Same author

MiR-877-5p targets PDK-1 to promote aspirin-induced apoptosis in gastric mucosal cells.

Die Pharmazie·2021

Same author

The mechanism of miR-363-3p/DUSP10 signaling pathway involved in the gastric mucosal injury induced by clopidogrel.

Toxicology mechanisms and methods·2020

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves

In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves

Published on: April 13, 2014

Function electrical stimulation signals generator circuits for the central nerve and the sciatic nerve.

Li Wenyuan¹, Zhang Zhenyu, Wang Zhi-Gong

¹Institute of RF- & OE-ICs, Southeast University, 210096 Nanjing, China.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

|February 7, 2007

Summary

New functional electrical stimulation (FES) circuits were developed using discrete components for central and sciatic nerve stimulation. These circuits offer adjustable gain and bandwidth, delivering precise current or voltage signals via microelectrodes.

More Related Videos

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

Related Experiment Videos

Last Updated: Jun 18, 2026

In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves

In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves

Published on: April 13, 2014

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

Area of Science:

Biomedical Engineering
Neuroscience
Electrical Engineering

Background:

Functional electrical stimulation (FES) is crucial for restoring function after nerve damage.
Existing FES systems often require complex circuitry or lack adaptability.
Targeted nerve stimulation necessitates precise signal generation tailored to specific nerve types.

Purpose of the Study:

To design and implement novel FES circuits for both central and sciatic nerve stimulation.
To achieve high performance characteristics, including variable gain and wide bandwidth.
To ensure compatibility with different microelectrode types for versatile application.

Main Methods:

Designed FES signal generation circuits using discrete operational amplifiers.
Implemented circuits with variable gain (20-60 dB) and bandwidth exceeding 10 kHz.
Utilized shaft microelectrodes for central nerve stimulation and cuff microelectrodes for sciatic nerve stimulation.

Main Results:

The central nerve stimulation circuit provides a current signal >1 mA into a kilo-ohm load.
The sciatic nerve stimulation circuit delivers a voltage signal >10 Vs into a kilo-ohm load.
Both circuits demonstrate robust performance with microelectrode loads.

Conclusions:

The developed discrete FES circuits effectively generate precise stimulation signals for central and sciatic nerves.
The adaptable gain and bandwidth make these circuits suitable for various FES applications.
These circuits represent a significant advancement in accessible and effective neurostimulation technology.