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Updated: Jul 17, 2026

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

A microcontroller-based implantable nerve stimulator used for rats.

Hong Sha¹, Zheng Zheng, Yan Wang

¹Inst. of Biomedical Engineering, CAMS&PUMC, POB25.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

|February 7, 2007

Summary

This study presents a tiny, implantable stimulator for rats that can be reprogrammed wirelessly after implantation using light pulses. This allows for customized experimental protocols and has been successfully demonstrated in animal behavior studies.

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Area of Science:

Biomedical Engineering
Neuroscience
Animal Research

Background:

Implantable stimulators are crucial for neuroscience research, but limited programmability post-implantation restricts experimental flexibility.
Developing advanced tools for precise neural modulation in animal models is essential for understanding brain function.

Purpose of the Study:

To develop and evaluate a miniaturized, wirelessly programmable microcontroller-based stimulator for use in freely moving rats.
To enable customized and complex stimulation protocols for behavioral experiments after device implantation.

Main Methods:

A microcontroller-based stimulator (1.6 cm³) was designed for post-implantation reprogramming via coded light pulse trains.
The stimulator updates its flash memory upon receiving and affirming new command parameters.

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Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Published on: July 14, 2020

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Last Updated: Jul 17, 2026

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Published on: July 14, 2020

The device was tested for functionality and successful application in rat behavior experiments.

Main Results:

The implantable stimulator demonstrated flexible, wireless programmability after surgical implantation in rats.
Customized stimulation protocols were successfully generated and delivered.
The device operated for one month and was validated in animal behavior studies.

Conclusions:

This reprogrammable implantable stimulator offers enhanced experimental control and flexibility for neuroscience research in rats.
The miniaturized, long-lasting device is suitable for complex behavioral studies requiring precise neural stimulation.