Related Experiment Video
Updated: Jul 17, 2026
09:24
Decellularization and Recellularization of Whole Livers
Published on: February 4, 2011
Construction of devices in bioartificial liver support system
Jianfeng Liu1, Ming Li, Wei Yang
1Graduate School of the Chinese Academy of Sciences, Beijing, 100049.
Summary
An automatic control device for Bioartificial Liver Support Systems was developed. This system ensures stable operation and precise control of critical parameters, potentially improving clinical outcomes.
Area of Science:
- Biomedical Engineering
- Control Systems Engineering
- Hepatology
Background:
- Bioartificial Liver Support Systems (BLSS) require precise environmental control for hepatocyte function.
- Existing control systems face challenges due to strong coupling, dead-delay, and non-linear factors in bioreactors.
Purpose of the Study:
- To design and implement an automatic control device for a BLSS.
- To ensure precise control of dissolved oxygen, pH, and temperature for optimal hepatocyte culture and metabolism.
Main Methods:
- Utilized an industrial control computer (WS-843AW) and precision electromagnetic valves for gas flux control (O2, CO2, N2).
- Implemented a Proportional-Integral (PI) controller combined with on-line and off-line predictive control algorithms.
- Analyzed parameter interconnections using mass balance equations and logic judgments from sensor signals.
Main Results:
- Achieved stable operation with high control precision for dissolved oxygen (±5%), pH (±0.05), and temperature (±0.1°C).
- Demonstrated effective control despite bioreactor complexities like strong coupling and non-linearities.
- Developed software using Visual C++ ensuring system reliability and maneuverability.
Conclusions:
- The developed automatic control device operates reliably in a steady state.
- The high control precision meets the demanding requirements of BLSS.
- This technology holds promise for improving the clinical therapeutic efficacy of BLSS.
