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Continuous-wave Near-infrared Topography System and Its Clinical Application
Canxing Xu1, Daifa Wang, Yonghong Zhang
1Dept. of Biomed. Eng., Tsinghua Univ., Beijing.
Summary
We created a new near-infrared spectroscopy topography system to image cerebral blood volume. This system shows promise for clinical applications and brain activity research, including acupuncture studies.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Medical Imaging
Background:
- Near-infrared spectroscopy (NIRS) is a non-invasive optical technique used to measure brain activity.
- Continuous-wave NIRS (CW-NIRS) offers advantages in cost and simplicity for brain imaging.
- Developing advanced NIRS systems is crucial for understanding cerebral hemodynamics.
Purpose of the Study:
- To develop and validate a reflectance continuous-wave near-infrared spectroscopy topography (rCW-NIRS-T) system.
- To assess the system's capability in reconstructing images of cerebral blood volume (CBV) variations.
- To explore the system's potential in clinical applications and brain activity research.
Main Methods:
- Designed a novel multi-source and multi-detector sensor head for the rCW-NIRS-T system.
- Utilized a single wavelength (808 nm) laser diode as the light source.
- Employed a differential measurement approach for image reconstruction.
- Conducted phantom experiments to verify system performance.
- Performed clinical experiments to investigate brain activity during acupuncture.
Main Results:
- Successfully developed a functional rCW-NIRS-T system.
- Demonstrated the system's ability to reconstruct images reflecting changes in cerebral blood volume.
- Phantom experiments validated the system's performance and accuracy.
- Preliminary results from clinical studies on acupuncture-induced brain activity were obtained.
Conclusions:
- The developed rCW-NIRS-T system is a viable tool for imaging cerebral blood volume.
- The system shows potential for diverse clinical applications and neuroscientific research.
- Further investigation is warranted to fully explore its capabilities in brain activity monitoring, particularly in response to stimuli like acupuncture.
