Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A combinatorial method for predicting genetic susceptibility to complex diseases.

Weidong Mao1, Jingwu He, Dumitru Brinza

  • 1Department of Computer Science, Georgia State University, Atlanta, GA 30303, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and recommendations in establishing national human diversity genomic projects.

Nature methods·2026
Same author

Exercise Improves Atherosclerotic Plaque Stability Through Macrophage Autophagy and the FGF21 Signaling Pathway.

International journal of molecular sciences·2026
Same author

Uncovering Epistatic Interactions in SARS-CoV-2 Evolution Through Hidden Markov Models.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same author

SARS-CoV-2 wastewater genomic surveillance: approaches, challenges, and opportunities.

Genome biology·2026
Same author

The influence of diabetes mellitus on blood vessels' amounts and immune status in case of breast cancer.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie·2025
Same author

Comprehensive first-in-human phase I/II study of FHND-9041 in patients with EGFR-mutated advanced non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands)·2025
Same journal

Highly Articulated Robotic Probe for Minimally Invasive Surgery.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2010
Same journal

Combined peripheral and cortical neural stimulation in motor neurorehabilitation.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Embedded assessment algorithms within home-based cognitive computer game exercises for elders.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Digital signal processing of the wideband external pulse recorded during cuff deflation: a new way to measure blood pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

wHospital: a web-based application with digital signature for drugs dispensing management.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
See all related articles

Combinatorial methods show promise for predicting disease susceptibility using genetic data. These approaches achieved up to 77.78% accuracy for Crohn's disease and 64.99% for autoimmune disorders.

Area of Science:

  • Genetics
  • Computational Biology
  • Medical Informatics

Background:

  • High-throughput genotyping advancements increase focus on disease association studies.
  • Predicting disease susceptibility is crucial for early intervention and personalized medicine.

Purpose of the Study:

  • To explore the application of combinatorial methods for disease susceptibility prediction.
  • To evaluate the efficacy of these novel methods against standard statistical approaches.

Main Methods:

  • Publicly available genotype data for Crohn's disease and autoimmune disorders were utilized.
  • Proposed combinatorial algorithms and standard statistical methods were applied.
  • Leave-one-out and leave-many-out cross-validation techniques were employed for assessment.

Related Experiment Videos

Main Results:

  • The proposed combinatorial algorithms achieved a prediction rate of 77.78% for Crohn's disease.
  • A prediction rate of 64.99% was achieved for autoimmune disorders.
  • Performance was assessed by predicting unknown disease statuses.

Conclusions:

  • Combinatorial methods offer a viable approach for disease susceptibility prediction.
  • These methods demonstrate competitive performance compared to traditional statistical techniques.
  • Further research can refine these algorithms for broader clinical application.