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Updated: Jul 17, 2026
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A Murine Model of Carotid Aneurysm Formation
Published on: September 9, 2025
A Model-based Numerical Analysis in the Early Development of Intracranial Aneurysms
Yixiang Feng1, Shigeo Wada, Ken-Ichi Tsubota
1Dept. of Bioeng. & Robotics, Tohoku Univ., Sendai.
Summary
Hemodynamic stress causes arterial wall degeneration, leading to intracranial aneurysm formation. Computer simulations show this degeneration, influenced by wall shear stress, drives aneurysm growth, especially in curved arteries.
Area of Science:
- Biomedical Engineering
- Computational Fluid Dynamics
- Vascular Biology
Background:
- Hemodynamic stresses contribute to intracranial aneurysm pathogenesis.
- Understanding the interplay between mechanical forces and arterial wall properties is crucial.
Purpose of the Study:
- To simulate intracranial aneurysm formation and growth.
- To investigate the relationship between wall shear stress, mechanical property degeneration, and wall deformation.
Main Methods:
- Numerical modeling of aneurysm formation in straight and curved arteries.
- Hypothesizing a threshold wall shear stress causing linear mechanical property decrease.
- Simulating the feedback loop between wall degeneration, deformation, and shear stress redistribution.
Main Results:
- Aneurysm development observed in both straight and curved arterial models.
- Curved models showed continuous growth, while straight models exhibited limited growth.
- Aneurysm development can occur even with low intra-aneurysmal wall shear stress due to proximal/distal wall degeneration.
Conclusions:
- The interaction between geometric changes and wall degeneration is key to aneurysm development.
- Model-based numerical methods offer utility in studying intracranial aneurysm developmental biology.