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Finite Element Modelling of a Cellular Electric Microenvironment
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Simulation-Based Training In Electrophysiology By iCELL.

Semahat Demir1

  • 1Program Director, Biomedical Engineering & Research to Aid Persons with Disabilities, Division of Bioengineering and Environmental Systems, National Science Foundation, 4201 Wilson Blvd. Suite 565, Arlington, VA 22230, USA; Faculty of Joint Biomedical Engineering Program, University of Memphis & University of Tennessee, 330 Engineering Technology Building, Memphis TN, 38152-3210, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 7, 2007
PubMed
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A new interactive cell modeling tool (iCell) offers simulation-based electrophysiology training. This computational resource models cellular bioelectric activity for teaching and research.

Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Electrophysiology

Background:

  • Electrophysiology education requires advanced tools for understanding complex cellular bioelectric activity.
  • Traditional teaching methods may not fully capture the dynamic nature of cellular electrophysiology.

Purpose of the Study:

  • To introduce the interactive cell modeling tool (iCell), a simulation-based resource for electrophysiology.
  • To provide a platform for computational modeling of cellular bioelectric activity for educational and research purposes.

Main Methods:

  • Development of a JAVA-based interactive tool (iCell) featuring menu-driven models of cardiac cells and neurons.
  • Inclusion of options to modify model parameters and conditions, and to visualize simulation data of bioelectric activities.

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Last Updated: Jul 17, 2026

Finite Element Modelling of a Cellular Electric Microenvironment
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  • Utilizing the tool in graduate courses and by international scientists for teaching, learning, and collaboration.

    • Main Results:

    • iCell successfully serves as a simulation-based teaching and learning tool in graduate-level electrophysiology courses.
    • The tool has been adopted and validated by scientists across biosciences, engineering, life sciences, and medicine in 17 countries.
    • Provides accessible simulation data for single-cell bioelectric activities.

    Conclusions:

    • The interactive cell modeling tool (iCell) is an effective resource for electrophysiology education and research.
    • Simulation-based learning enhances the understanding of cellular bioelectric phenomena.
    • iCell fosters a collaborative environment for scientists globally.