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Updated: Jul 17, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Imaging of bioelectric sources in the heart using a cellular automaton model
1Institute of Biomedical Engineering, Universität Karlsruhe (TH), Germany.
Abstract:
The approach to solve the inverse problem of electrocardiography presented here is using a computer model of the individual heart of a patient. It is based on a 3D-MRI dataset. Electrophysiologically important tissue classes are incorporated using rules. Source distributions inside the heart are simulated using a cellular automaton. Finite Element Method is used to calculate the corresponding body surface potential map. Characteristic parameters like duration and amplitude of transmembrane potential or velocity of propagation are optimized for selected tissue classes or regions in the heart so that simulated data fit to the measured data. This way the source distribution and its time course of an individual patient can be reconstructed.
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