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Updated: Jul 17, 2026

Thermal Measurement Techniques in Analytical Microfluidic Devices
Published on: June 3, 2015
Theory and Experiments of MEMS Thermal Biosensors
1Mechanical Engineering Department, Carnegie Mellon University, 5000 Forbes Ave., Pittsburgh, PA 15213 USA (phone: 412-2682514;e-mail: liw@andrew.cmu.edu).
Abstract:
This paper presents a theoretical and experimental investigation of MEMS thermal biosensors in flow-through measurements of metabolites. A model is developed to consider convective heat transfer effects and enzyme kinetics using the Michaelis-Menton theory. Numerical solutions from the model are compared with experimental data obtained from a prototype MEMS thermal biosensor. Satisfactory agreement is found between the theoretical and experimental results, indicating that the model is useful for designing MEMS thermal biosensors with optimized performance.
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