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Updated: Jul 17, 2026

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
Published on: January 19, 2020
A combined haemodynamic and biochemical model of cerebral autoregulation
Stephen Payne1, Henry Morris, Alexander Rowley
1Dept. of Eng. Sci., Oxford Univ.
Abstract:
The feedback processes that control the blood supply to the brain, collectively termed cerebral autoregulation, are many and complex. Failure of this mechanism is implicated in a number of conditions. However, in a clinical setting the number of variables that can be measured non-invasively is extremely limited. In addition, current models are either too crude, and not physiologically meaningful, or so complex that analysis is difficult. In this paper a new compact, but physiologically meaningful, model is presented, based on smooth muscle cells within a vessel model, integrated within a full haemodynamic model. Preliminary results show realistic behaviour.
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