Related Experiment Video
Updated: Jul 17, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
A Neural Network to Locate the Copper-binding sites of Metalloprotein
1Sch. of Life Sci. & Technol., Univ. of Electron. Sci. & Technol. of China, Chengdu.
Abstract:
This paper presents an application of neural networks in location of the copper-binding sites of metalloprotein. Using annotated metalloprotein downloaded from PDB, sequences including copper-binding sites were extracted. By further finding the particular core segments of copper-binding sites, the input and output information for training is polished. Moreover, this paper investigates the number of input nodes whose input information was coded by the residues' hydrophobic values, the number of hidden nodes, the size of training window. Back propagation algorithms were chosen for training neural networks. Results showed that the method was capable of efficiently identifying copper-binding proteins and predicting copper-binding sites at a very high accuracy.
More Related Videos
11:04Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
Published on: September 7, 2019
11:38Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
Related Concept Videos
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Ligand Binding and Linkage
Ligand Binding Sites
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Protein-protein Interfaces
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...