Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SMA: An Efficient Tool for Large-Scale Multiple Alignment.

Shiyi Shen1, Liuhuan Dong, Kui Wang

  • 1School of Mathematics and LPMC, Nankai University, Tianjin 300071, China.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis.

Biochemical and biophysical research communications·2016
Same author

Are Children Like Werewolves? Full Moon and Its Association with Sleep and Activity Behaviors in an International Sample of Children.

Frontiers in pediatrics·2016
Same author

MAP30 inhibits autophagy through enhancing acetyltransferase p300 and induces apoptosis in acute myeloid leukemia cells.

Oncology reports·2016
Same author

Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53.

Neuropharmacology·2016
Same author

Physical activity, sedentary behaviors and risk of gestational diabetes mellitus: a population-based cross-sectional study in Tianjin, China.

European journal of endocrinology·2016
Same author

Building Structured Personal Health Records from Photographs of Printed Medical Records.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2016
Same journal

Highly Articulated Robotic Probe for Minimally Invasive Surgery.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2010
Same journal

Combined peripheral and cortical neural stimulation in motor neurorehabilitation.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Embedded assessment algorithms within home-based cognitive computer game exercises for elders.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Digital signal processing of the wideband external pulse recorded during cuff deflation: a new way to measure blood pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

wHospital: a web-based application with digital signature for drugs dispensing management.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
See all related articles

Biologists need efficient tools for aligning large virus genomic sequences. SMA is a new, fast, and accurate multiple sequence alignment tool for handling hundreds of sequences, improving upon existing methods.

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Accurate alignment of large-scale viral genomic sequences is crucial for evolutionary and epidemiological studies.
  • Existing multiple sequence alignment tools struggle with the computational demands of hundreds or thousands of sequences.

Purpose of the Study:

  • To introduce SMA, a novel and efficient tool for high-volume multiple sequence alignment.
  • To provide a faster and accurate alternative for analyzing large sets of viral genomic data.

Main Methods:

  • Development of a new algorithm for multiple sequence alignment.
  • High-throughput testing using 706 Human Immunodeficiency Virus type 1 (HIV-1) genomic sequences.

Main Results:

Related Experiment Videos

  • SMA demonstrates significantly higher speed compared to existing programs.
  • SMA achieves comparable or improved accuracy in aligning conserved genomic features.
  • The tool effectively handles large datasets, as shown by the HIV-1 test case.

    • Conclusions:

    • SMA represents a significant advancement in multiple sequence alignment for large viral genomic datasets.
    • The tool offers a practical solution for biologists requiring efficient and accurate sequence analysis.
    • SMA is freely available, promoting wider accessibility in research.