Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain tissue segmentation based on corrected gray-scale analysis.

Jinghua Wang1, Maolin Qiu, Xenophon Papademetris

  • 1Yale University School Medical Center, The Anlyan Center, 300 Cedar Street, New Haven, CT 06520, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic and Prognostic Utility of Plasma p-tau217 for Alzheimer's Disease in Chinese Elderly: Insights From the SILCODE Study With a Derived Threshold.

European journal of neurology·2026
Same author

Salinity reduces cadmium bioavailability and toxicity in the Oryzias melastigma: Evidence from fish exposure and cell-based ion-competition assays.

Marine pollution bulletin·2026
Same author

CAD-SEL: A dual-modal colonoscopy dataset of subepithelial lesion.

Scientific data·2026
Same author

Vision-Based Measurement of Breathing Deformation in Wind Turbine Blade Fatigue Test.

Journal of imaging·2026
Same author

Characteristics and clinical significance of aortic ulcer signs on computed tomography angiography in patients with Takayasu's arteritis.

Clinical and experimental rheumatology·2026
Same author

Elevated plasma klotho levels attenuate Alzheimer's disease pathologies and cognitive decline in APOE ε4 carriers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Highly Articulated Robotic Probe for Minimally Invasive Surgery.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2010
Same journal

Combined peripheral and cortical neural stimulation in motor neurorehabilitation.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Embedded assessment algorithms within home-based cognitive computer game exercises for elders.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Digital signal processing of the wideband external pulse recorded during cuff deflation: a new way to measure blood pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

wHospital: a web-based application with digital signature for drugs dispensing management.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
See all related articles

Optimizing magnetic resonance imaging (MRI) parameters improves brain tissue segmentation accuracy. A new method effectively corrects signal intensity inhomogeneities, leading to precise brain MR image analysis.

Area of Science:

  • Medical Imaging
  • Neuroimaging
  • Biomedical Engineering

Background:

  • Signal-to-noise ratio (SNR) and signal intensity (SI) inhomogeneities in brain MRI data significantly impact the accuracy of tissue segmentation.
  • Precise brain tissue segmentation is crucial for diagnosing neurological disorders and monitoring treatment efficacy.

Purpose of the Study:

  • To optimize SNR and contrast in multi-spectrum MRI datasets by adjusting TR and inversion recovery time (TI).
  • To implement and evaluate a novel method for in vivo correction of SI inhomogeneities.
  • To improve the accuracy and precision of brain tissue segmentation using an Expectation-Maximization (EM) algorithm.

Main Methods:

  • Optimized SNR and contrast by adjusting TR and TI parameters in multi-spectrum MRI datasets.

Related Experiment Videos

  • Measured in vivo SI inhomogeneities using a newly developed correction method.
  • Employed a three-Gaussian distribution model for histogram fitting to obtain initialization parameters for the EM segmentation algorithm.
  • Utilized a field map method for SI inhomogeneity correction.

    • Main Results:

    • The proposed method successfully optimized SNR and contrast in brain MRI datasets.
    • The developed technique provided improved correction of SI inhomogeneities compared to existing methods.
    • The EM segmentation algorithm, initialized with parameters from the three-Gaussian model and corrected SI data, yielded excellent segmentation results.

    Conclusions:

    • Optimizing MRI acquisition parameters and applying advanced correction techniques significantly enhance brain tissue segmentation.
    • The field map method offers superior correction of SI inhomogeneities, leading to more accurate and precise brain MR image segmentation.
    • This approach provides a robust framework for improving the reliability of quantitative analysis in neuroimaging studies.