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Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection
Amanda C Jacobson1, Ying Ma, James F Zachary
1Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112-5650, USA.
Infection and Immunity
|February 7, 2007
Abstract:
CD21/35(-/-) mice, deficient in CD21 and CD35 (complement receptors 2 and 1, respectively), were infected with Borrelia burgdorferi to assess the role of these receptors in a chronic bacterial infection. Although CD21/35(-/-) mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar.
