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Published on: January 28, 2020
Interaction between C-reactive protein and endothelin-1 in coronary artery disease
Gökmen Gemici1, Refik Erdim, Sena Tokay
1Marmara University School of Medicine, Istanbul, Turkey. kardiyolog@ttnet.net.tr
Insights
This study investigated the link between C-reactive protein (CRP) and endothelin-1 (ET-1) in coronary artery disease (CAD). No significant correlation was found overall, but a link emerged in patients not taking statins.
Area of Science:
- Cardiovascular Medicine
- Biomarker Research
Background:
- Elevated C-reactive protein (CRP) predicts cardiovascular events in coronary artery disease (CAD).
- Increased endothelin-1 (ET-1) is linked to poor prognosis post-myocardial infarction.
Purpose of the Study:
- To test if ET-1 contributes to CRP's predictive value for adverse outcomes in CAD.
- Investigate the relationship between CRP and ET-1 in stable CAD patients.
Main Methods:
- Measured serum high-sensitivity CRP and plasma ET-1 in 40 stable CAD patients and 25 controls.
- Performed correlation analysis between CRP and ET-1 levels.
Main Results:
- No statistically significant correlation between CRP and ET-1 in the overall CAD group (p=0.82) or controls (p=0.85).
- A strong correlation (p=0.01) was observed between CRP and ET-1 in a subgroup of 13 patients not on statin treatment.
Conclusions:
- The study does not definitively confirm or deny a link between CRP and ET-1 in stable CAD.
- A potential association may exist in CAD patients not receiving statin therapy.
Background:
Increased concentrations of serum C-reactive protein (CRP) have been reported to predict major cardiovascular events in patients with coronary artery disease (CAD). Increased concentrations of endothelin-1 (ET-1) are also associated with poor prognosis after myocardial infarction.
Hypothesis:
We tested the hypothesis that ET-1 might contribute to CRP in prediction of adverse outcome in CAD.
Methods:
Serum high sensitive CRP and plasma ET-1 levels of 40 patients who have stable CAD and 25 control subjects were measured, and correlation analysis between these molecules was performed.
Results:
Mean high sensitive CRP was 8.64 +/- 12.73 mg/l, and mean ET-1 was 8.24 +/- 7.06 pg/ml in the CAD group. We found that there was no statistically significant correlation between high sensitive CRP and ET-1 in either CAD group (p = 0.82), or the control group (p = 0.85). In a subgroup of 13 patients who were not under statin treatment, we found a strong correlation between the levels of these molecules (p = 0.01).
Conclusion:
Our study does not clearly support or exclude a link between CRP and ET-1 in patients who have stable CAD.
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