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C-reactive protein distribution and correlates among men and women with chronic coronary heart disease

M Benderly1, M Haim, V Boyko

  • 1The Israel Society for the Prevention of Heart Attacks, Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer, Israel. bender@post.tau.ac.il

Cardiology
|February 7, 2007
PubMed

Insights

C-reactive protein (CRP) levels are higher in women with coronary heart disease (CHD). Body mass index (BMI) significantly influences CRP levels, especially in women, highlighting its role in cardiovascular health.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • C-reactive protein (CRP) is an inflammation marker linked to atherosclerotic disease.
  • Understanding CRP distribution and its relationship with coronary heart disease (CHD) risk factors is crucial.

Purpose of the Study:

  • To analyze C-reactive protein (CRP) levels and their association with coronary heart disease (CHD) risk factors in a large patient cohort.
  • To investigate differences in CRP distribution and influencing factors between men and women with CHD.

Main Methods:

  • Analysis of 2,723 male and 256 female CHD patients from the Bezafibrate Infarction Prevention (BIP) study.
  • Quantification of high-sensitive CRP levels in frozen plasma samples.

Main Results:

  • CRP levels were higher in women than men (4.4 vs. 3.5 mg/l) across all age groups.
  • Co-morbidities, smoking, lower education, and cardiovascular drug use correlated with elevated CRP in both sexes.
  • Body mass index (BMI) showed a stronger correlation with CRP in women, explaining 10% of CRP variability, compared to men (13% total explained variability).

Conclusions:

  • CRP levels in men and women with CHD correlate with traditional risk factors, though to a lesser extent with CHD manifestation.
  • Body mass index (BMI) is the primary contributor to CRP variability among women with CHD.
Abstract

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