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Polymorphism in apoprotein-CIII gene and coronary heart disease

S S Hussain1, J Buraiki, N Dzimiri

  • 1Departments of Biological and Medical Research, Cardiovascular Diseases, and Biomedical Statistics and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Annals of Saudi Medicine
|February 7, 2007
PubMed

Insights

The apoprotein-CIII variant allele is not linked to high cholesterol or triglycerides. However, this genetic marker significantly increases the risk of coronary heart disease (CHD) in Saudi subjects.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • Apolipoprotein-CIII (Apo-CIII) plays a role in lipid metabolism.
  • Genetic variations in Apo-CIII may influence lipid levels and cardiovascular risk.
  • Previous studies have suggested potential links between Apo-CIII and dyslipidemia or coronary heart disease (CHD).

Purpose of the Study:

  • To investigate the association between an apoprotein-CIII variant allele and hypertriglyceridemia, hypercholesterolemia, and coronary heart disease (CHD).

Main Methods:

  • Genotyping of a C to G substitution in the 3' untranslated region of apoprotein-CIII was performed.
  • The study included 92 Saudi subjects (65 males, 27 females) who underwent coronary angiography.
  • Restriction fragment length polymorphism analysis using Sac I was employed for genotyping.

Main Results:

  • The Apo-CIII variant allele showed no significant association with hypertriglyceridemia or hypercholesterolemia.
  • A significant association (P<0.01) was observed between the Apo-CIII variant allele and coronary heart disease (CHD).
  • Individuals with the rare allele had a 3.4-fold increased risk of CHD, independent of other risk factors, even in those over 45.

Conclusions:

  • The study did not establish a link between the apoprotein-CIII variant allele and dyslipidemia (hypertriglyceridemia or hypercholesterolemia).
  • A significant association was found between the apoprotein-CIII variant allele and an increased risk of coronary heart disease (CHD) in the studied Saudi population.
Abstract

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