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Updated: Jul 17, 2026
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Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Infiltrates in protocol biopsies from renal allografts
Summary
Persistent inflammation in kidney transplant biopsies, regardless of type, predicts allograft function. This finding suggests that even minor cellular infiltrates, not currently classified by Banff criteria, indicate ongoing kidney damage.
Area of Science:
- Nephrology
- Transplantation Immunology
- Pathology
Background:
- Clinical decisions in renal transplantation rely on the Banff classification of biopsies.
- The significance of minor or nonspecific cellular infiltrates in Banff classification is unclear.
Purpose of the Study:
- To determine if minor or nonspecific cellular infiltrates impact renal allograft outcomes.
- To correlate infiltrate characteristics with Banff classification and patient outcomes.
Main Methods:
- Analysis of 833 protocol and 306 indicated renal allograft biopsies.
- Characterization of infiltrate morphology, localization, and cellular composition.
- Correlation of findings with Banff classification and allograft function.
Main Results:
- Prevalence of infiltrates was similar in protocol and indication biopsies (87%).
- Persistent inflammation in sequential biopsies, irrespective of infiltrate type, predicted allograft function outcome.
- All infiltrate types and cell types increased in biopsies with Banff-defined cellular rejection.
Conclusions:
- Persistent inflammation in sequential biopsies is a key indicator of ongoing allograft damage.
- Infiltrates not currently considered by Banff classification may signify damage.
- Re-evaluation of Banff criteria to include all persistent inflammatory infiltrates is warranted.
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