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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
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Magnetic-fluorescent nanocomposites for biomedical multitasking.

Serena A Corr1, Aisling O'Byrne, Yurii K Gun'ko

  • 1School of Chemistry. Trinity College Dublin, Dublin 2, Ireland.

Chemical Communications (Cambridge, England)
|February 8, 2007
PubMed
Summary

Fluorescent magnetite nanocomposites were created using magnetic nanoparticles and a porphyrin derivative. These novel materials show promise for cellular imaging and as magnetic resonance imaging (MRI) contrast agents.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Development of advanced nanomaterials for biomedical applications is crucial.
  • Magnetic nanoparticles offer unique properties for imaging and diagnostics.
  • Silsesquioxanes and porphyrins can be functionalized for targeted delivery and imaging.

Purpose of the Study:

  • To synthesize and characterize novel fluorescent magnetite nanocomposites.
  • To evaluate the cellular uptake of these nanocomposites in relevant cell types.
  • To assess the potential of the nanocomposites as magnetic resonance imaging (MRI) contrast agents.

Main Methods:

  • Preparation of nanocomposites integrating magnetic nanoparticles, octaaminopropylsilsesquioxane, and a porphyrin derivative.
  • In vitro studies involving incubation with macrophage and bone osteoblast cells.
  • Assessment of cellular uptake using fluorescence microscopy.
  • Evaluation of MRI contrast enhancement properties.

Main Results:

  • Successful synthesis of fluorescent magnetite nanocomposites.
  • Demonstrated intracellular uptake by both macrophage and bone osteoblast cells.
  • Preliminary evidence suggests potential as MRI contrast agents.

Conclusions:

  • Fluorescent magnetite nanocomposites are effectively internalized by target cells.
  • These nanocomposites hold promise for multimodal bioimaging.
  • Further investigation is warranted for their application as MRI contrast agents.